Motif ID: STAT5{A,B}.p2

Z-value: 2.138


Transcription factors associated with STAT5{A,B}.p2:

Gene SymbolEntrez IDGene Name
STAT5A 6776 signal transducer and activator of transcription 5A
STAT5B 6777 signal transducer and activator of transcription 5B

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
STAT5Bchr17_-_37681917-0.712.2e-03Click!
STAT5Achr17_+_37694007-0.312.4e-01Click!


Activity profile for motif STAT5{A,B}.p2.

activity profile for motif STAT5{A,B}.p2


Sorted Z-values histogram for motif STAT5{A,B}.p2

Sorted Z-values for motif STAT5{A,B}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT5{A,B}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_49248003 4.682 NM_013361
ZNF223
zinc finger protein 223
chr5_+_145297490 3.729 SH3RF2
SH3 domain containing ring finger 2
chr7_-_93471463 3.508 NM_005868
BET1
blocked early in transport 1 homolog (S. cerevisiae)
chr19_-_49552638 3.346 NM_001083335
NM_013380
ZFP112

zinc finger protein 112 homolog (mouse)

chr19_+_49180171 2.898 NM_003445
NM_198089
ZNF155

zinc finger protein 155

chr11_-_33678861 2.810 NM_001166692
C11orf91
chromosome 11 open reading frame 91
chr19_+_49198916 2.554 NM_006300
ZNF230
zinc finger protein 230
chr19_+_49290319 2.503 NM_013398
ZNF224
zinc finger protein 224
chr7_+_89870647 2.366 NM_001185072
NM_001185073
NM_012129
CLDN12


claudin 12


chr7_+_89870707 2.354 CLDN12
claudin 12
chr11_+_65024889 2.348 MALAT1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr14_-_67232172 2.194 NM_016026
RDH11
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
chr6_+_28156460 2.159 NM_003447
ZNF165
zinc finger protein 165
chrX_+_105932536 2.150 NM_017752
NM_198881
TBC1D8B

TBC1 domain family, member 8B (with GRAM domain)

chr15_+_39853982 2.147 MAPKBP1
mitogen-activated protein kinase binding protein 1
chr11_-_82674546 2.088 CCDC90B
coiled-coil domain containing 90B
chr12_+_12857516 2.064 NM_016355
NM_201224
DDX47

DEAD (Asp-Glu-Ala-Asp) box polypeptide 47

chr19_+_49361054 2.060 NM_001146220
NM_001032373
NM_001032374
NM_015919
NM_001032372
ZNF226




zinc finger protein 226




chr6_-_30766621 1.930 NM_007243
NRM
nurim (nuclear envelope membrane protein)
chr9_-_133945064 1.881 NM_004269
CRSP8P
MED27
mediator complex subunit 27 pseudogene
mediator complex subunit 27
chr19_+_42033106 1.877 NM_003419
ZNF345
zinc finger protein 345
chr9_-_133944877 1.810 MED27
mediator complex subunit 27
chr3_+_197951203 1.803 PAK2
p21 protein (Cdc42/Rac)-activated kinase 2
chr19_+_62638474 1.724 NM_001023561
ZNF749
zinc finger protein 749
chr6_-_32892705 1.706 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr17_+_36515166 1.693 NM_001146041
KRTAP4-9
keratin associated protein 4-9
chr19_+_42400908 1.653 ZNF383
zinc finger protein 383
chr19_-_49500966 1.603 NM_004234
ZNF235
zinc finger protein 235
chr3_+_197951121 1.601 NM_002577
PAK2
p21 protein (Cdc42/Rac)-activated kinase 2
chr20_-_18425811 1.590 NM_006606
RBBP9
retinoblastoma binding protein 9
chr19_+_49309350 1.571 NM_013362
ZNF225
zinc finger protein 225
chr4_+_130236731 1.561 NM_001099783
C4orf33
chromosome 4 open reading frame 33
chr19_-_62912347 1.554 NM_001085384
ZNF154
zinc finger protein 154
chr19_+_49023283 1.541 NM_181845
ZNF283
zinc finger protein 283
chr9_-_103200697 1.524 NM_019051
MRPL50
mitochondrial ribosomal protein L50
chr14_-_69953433 1.496 NM_018373
SYNJ2BP
synaptojanin 2 binding protein
chr4_+_86615275 1.489 NM_001025616
ARHGAP24
Rho GTPase activating protein 24
chr1_-_151788341 1.432 NM_002960
S100A3
S100 calcium binding protein A3
chr15_+_39853923 1.428 NM_001128608
NM_014994
MAPKBP1

mitogen-activated protein kinase binding protein 1

chr19_-_63018092 1.383 NM_024762
ZNF552
zinc finger protein 552
chr15_+_88696480 1.382 NM_001004309
ZNF774
zinc finger protein 774
chr5_+_137542652 1.355 KIF20A
kinesin family member 20A
chr6_+_139136349 1.326 NM_015439
CCDC28A
coiled-coil domain containing 28A
chr19_+_42099073 1.310 NM_198539
ZNF568
zinc finger protein 568
chr2_+_43854681 1.297 NM_001193464
NM_015522
NM_016008
DYNC2LI1


dynein, cytoplasmic 2, light intermediate chain 1


chr3_+_199161446 1.273 NM_000996
RPL35A
ribosomal protein L35a
chr10_+_86174665 1.268 FAM190B
family with sequence similarity 190, member B
chr19_-_49309102 1.249 LOC100379224
hypothetical LOC100379224
chr19_-_41849558 1.244 NM_153257
ZNF461
zinc finger protein 461
chr3_+_140545528 1.200 NM_020191
MRPS22
mitochondrial ribosomal protein S22
chr9_+_103200939 1.198 NM_003452
NM_197977
ZNF189

zinc finger protein 189

chr20_+_12937616 1.158 NM_018327
SPTLC3
serine palmitoyltransferase, long chain base subunit 3
chr8_-_109330101 1.147 EIF3E
eukaryotic translation initiation factor 3, subunit E
chr14_+_67356248 1.143 NM_002877
NM_133509
NM_133510
RAD51L1


RAD51-like 1 (S. cerevisiae)


chr3_+_132228383 1.140 NM_001146003
NM_024800
NM_145910
NEK11


NIMA (never in mitosis gene a)- related kinase 11


chr6_-_46728188 1.128 NM_016593
CYP39A1
cytochrome P450, family 39, subfamily A, polypeptide 1
chr2_+_69974581 1.127 NM_006857
SNRNP27
small nuclear ribonucleoprotein 27kDa (U4/U6.U5)
chr19_+_17239264 1.123 BABAM1
BRISC and BRCA1 A complex member 1
chr15_+_40427592 1.120 NM_212465
CAPN3
calpain 3, (p94)
chr8_-_109330116 1.112 NM_001568
EIF3E
eukaryotic translation initiation factor 3, subunit E
chrX_+_46935152 1.111 UBA1
ubiquitin-like modifier activating enzyme 1
chr1_-_109420091 1.099 NM_005645
TAF13
TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
chr19_+_9112052 1.099 NM_001190791
NM_020933
ZNF317

zinc finger protein 317

chr2_-_85435074 1.089 NM_017750
RETSAT
retinol saturase (all-trans-retinol 13,14-reductase)
chr19_+_45168872 1.086 NM_006503
NM_153001
PSMC4

proteasome (prosome, macropain) 26S subunit, ATPase, 4

chr2_+_95195260 1.081 ZNF2
zinc finger protein 2
chr1_-_54291378 1.058 TMEM59
transmembrane protein 59
chr5_+_137542315 1.032 NM_005733
KIF20A
kinesin family member 20A
chr9_+_129226535 1.029 ZNF79
zinc finger protein 79
chr9_+_129226473 1.020 NM_007135
ZNF79
zinc finger protein 79
chr3_+_171422940 1.016 PRKCI
protein kinase C, iota
chr1_+_40769877 1.003 ZNF684
zinc finger protein 684
chr19_-_42777486 1.003 NM_016536
ZNF571
zinc finger protein 571
chr19_+_42033564 1.001 ZNF345
zinc finger protein 345
chr19_+_17239148 0.990 NM_001033549
NM_014173
BABAM1

BRISC and BRCA1 A complex member 1

chr1_-_54291634 0.983 NM_004872
TMEM59
transmembrane protein 59
chr2_+_63669596 0.981 NM_005917
MDH1
malate dehydrogenase 1, NAD (soluble)
chr19_-_56196611 0.976 NM_007196
NM_144505
NM_144506
NM_144507
KLK8



kallikrein-related peptidase 8



chr15_-_81744469 0.966 NM_001717
BNC1
basonuclin 1
chr14_+_23700261 0.960 NM_006084
IRF9
interferon regulatory factor 9
chr5_-_137542198 0.921 NM_001164326
NM_006696
NM_139199
BRD8


bromodomain containing 8


chr6_+_20642665 0.896 NM_017774
CDKAL1
CDK5 regulatory subunit associated protein 1-like 1
chr7_+_75928907 0.893 NM_001102594
NM_001102595
NM_020892
DTX2


deltex homolog 2 (Drosophila)


chr19_+_49268106 0.891 NM_001037813
ZNF284
zinc finger protein 284
chr17_-_44847214 0.885 PHB
prohibitin
chr17_-_44847215 0.884 NM_002634
PHB
prohibitin
chr2_-_27739947 0.879 NM_014860
SUPT7L
suppressor of Ty 7 (S. cerevisiae)-like
chr14_-_19951417 0.878 NM_007110
TEP1
telomerase-associated protein 1
chr18_-_45241014 0.869 NM_017653
DYM
dymeclin
chr19_+_58733144 0.868 NM_001079906
ZNF331
zinc finger protein 331
chr2_-_230792844 0.848 NM_004509
NM_004510
NM_080424
SP110


SP110 nuclear body protein


chr19_-_42098758 0.847 NM_001171979
ZNF829
zinc finger protein 829
chr2_+_95194903 0.823 NM_001017396
NM_021088
ZNF2

zinc finger protein 2

chr1_+_54291847 0.822 NM_153035
TCEANC2
transcription elongation factor A (SII) N-terminal and central domain containing 2
chr1_-_33275051 0.822 AK2
adenylate kinase 2
chr1_-_54291503 0.816 TMEM59
transmembrane protein 59
chr19_+_58715988 0.812 NM_018555
ZNF331
zinc finger protein 331
chr1_-_54291474 0.796 TMEM59
transmembrane protein 59
chr19_-_51058177 0.786 NM_004819
SYMPK
symplekin
chr19_+_13090101 0.782 NM_052876
NACC1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr1_-_33275039 0.778 AK2
adenylate kinase 2
chr3_+_171422908 0.747 NM_002740
PRKCI
protein kinase C, iota
chr11_-_72182291 0.743 NM_006645
STARD10
StAR-related lipid transfer (START) domain containing 10
chr1_-_33275015 0.733 AK2
adenylate kinase 2
chr2_+_218843358 0.725 NM_001077399
NM_015488
PNKD

paroxysmal nonkinesigenic dyskinesia

chr19_-_49097774 0.719 LOC100505715
hypothetical LOC100505715
chr17_-_5263594 0.718 NUP88
nucleoporin 88kDa
chr19_+_49455872 0.715 NM_181756
ZNF233
zinc finger protein 233
chr19_-_3712621 0.710 NM_004886
APBA3
amyloid beta (A4) precursor protein-binding, family A, member 3
chr8_-_56848423 0.704 NM_152417
TMEM68
transmembrane protein 68
chr17_-_36792161 0.682 NM_021013
KRT34
keratin 34
chr3_+_171422917 0.679 PRKCI
protein kinase C, iota
chr4_+_174528602 0.675 NM_003864
SAP30
Sin3A-associated protein, 30kDa
chr19_-_41711009 0.672 NM_001012756
NM_001166036
NM_001166037
NM_001166038
ZNF260



zinc finger protein 260



chr19_-_56303434 0.670 NM_145232
CTU1
cytosolic thiouridylase subunit 1 homolog (S. pombe)
chr1_+_40769819 0.666 NM_152373
ZNF684
zinc finger protein 684
chr19_+_39860398 0.661 NM_001012320
NM_018443
ZNF302

zinc finger protein 302

chr7_+_92699588 0.645 NM_017667
NM_024553
CCDC132

coiled-coil domain containing 132

chr7_-_112545840 0.642 LOC401397
hypothetical LOC401397
chr4_+_174528675 0.637 SAP30
Sin3A-associated protein, 30kDa
chr21_-_35174742 0.630 RUNX1
runt-related transcription factor 1
chr17_-_17435631 0.625 NM_148172
PEMT
phosphatidylethanolamine N-methyltransferase
chr2_-_63669022 0.624 WDPCP
WD repeat containing planar cell polarity effector
chr8_-_66708967 0.622 NM_018120
ARMC1
armadillo repeat containing 1
chr3_+_185386556 0.620 NM_018358
ABCF3
ATP-binding cassette, sub-family F (GCN20), member 3
chr8_-_66708954 0.619 ARMC1
armadillo repeat containing 1
chr11_-_125278296 0.617 NM_031307
PUS3
pseudouridylate synthase 3
chr3_+_185386664 0.615 ABCF3
ATP-binding cassette, sub-family F (GCN20), member 3
chr19_-_42098919 0.611 NM_001037232
ZNF829
zinc finger protein 829
chr1_-_33275071 0.610 NM_013411
AK2
adenylate kinase 2
chrX_+_48219344 0.610 NM_012280
NM_177439
FTSJ1

FtsJ homolog 1 (E. coli)

chr8_-_66708948 0.603 ARMC1
armadillo repeat containing 1
chr7_+_128290092 0.597 NM_001198909
NM_004231
ATP6V1F

ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F

chr17_+_15543771 0.593 ZNF286A
zinc finger protein 286A
chr1_-_33275057 0.589 NM_001625
AK2
adenylate kinase 2
chr10_-_121345968 0.588 TIAL1
TIA1 cytotoxic granule-associated RNA binding protein-like 1
chr1_-_199704773 0.579 NM_012396
PHLDA3
pleckstrin homology-like domain, family A, member 3
chr2_-_63669085 0.569 WDPCP
WD repeat containing planar cell polarity effector
chr9_-_129226312 0.566


chr11_+_36572615 0.561 NM_138787
C11orf74
chromosome 11 open reading frame 74
chr3_+_181802592 0.545 NM_001042601
NM_133462
TTC14

tetratricopeptide repeat domain 14

chr19_-_62782066 0.535 ZNF416
zinc finger protein 416
chr14_+_22305570 0.533 NM_005015
OXA1L
oxidase (cytochrome c) assembly 1-like
chr3_-_132228273 0.530 NM_014065
ASTE1
asteroid homolog 1 (Drosophila)
chr7_+_47801413 0.529 NM_025031
PKD1L1
C7orf69
polycystic kidney disease 1 like 1
chromosome 7 open reading frame 69
chr2_-_63669265 0.527 NM_015910
WDPCP
WD repeat containing planar cell polarity effector
chr3_-_112796855 0.525 NM_024508
ZBED2
zinc finger, BED-type containing 2
chr19_-_49131250 0.513 NM_003425
ZNF45
zinc finger protein 45
chr19_-_62781883 0.513 NM_017879
ZNF416
zinc finger protein 416
chr8_-_99375739 0.497 NM_024759
NIPAL2
NIPA-like domain containing 2
chr4_-_153820535 0.497 NM_152680
TMEM154
transmembrane protein 154
chrX_+_46935035 0.491 NM_153280
UBA1
ubiquitin-like modifier activating enzyme 1
chr19_-_41672598 0.483 ZNF566
zinc finger protein 566
chr17_-_36528113 0.481 NM_033059
KRTAP4-11
keratin associated protein 4-11
chr10_-_62163083 0.471 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr19_+_61344341 0.470 NM_018337
ZNF444
zinc finger protein 444
chr1_+_38250953 0.470 NM_016037
UTP11L
UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast)
chr17_-_35464137 0.469 MED24
mediator complex subunit 24
chr19_+_49337548 0.461 NM_001144824
NM_006630
ZNF234

zinc finger protein 234

chr1_+_38250995 0.461 UTP11L
UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast)
chr16_+_52295545 0.456 FTO
fat mass and obesity associated
chr7_-_112545847 0.445 LOC401397
hypothetical LOC401397
chr22_+_37407906 0.442 TOMM22
translocase of outer mitochondrial membrane 22 homolog (yeast)
chr1_-_233734088 0.437 B3GALNT2
beta-1,3-N-acetylgalactosaminyltransferase 2
chr17_+_5264195 0.434 RPAIN
RPA interacting protein
chr1_+_153374900 0.432 NM_001122837
NM_001122839
NM_018845
SLC50A1


solute carrier family 50 (sugar transporter), member 1


chr6_+_84626146 0.431 CYB5R4
cytochrome b5 reductase 4
chr19_+_63022879 0.430 LOC100293516
zinc finger protein
chr19_+_49337568 0.411 ZNF234
zinc finger protein 234
chr5_+_145563305 0.410 RBM27
RNA binding motif protein 27
chr17_+_30938470 0.408 AP2B1
adaptor-related protein complex 2, beta 1 subunit
chr22_+_37407921 0.405 TOMM22
translocase of outer mitochondrial membrane 22 homolog (yeast)
chr11_+_2877486 0.405 NM_183233
SLC22A18
solute carrier family 22, member 18
chr12_-_102413875 0.402 NM_198521
NM_001099336
C12orf42

chromosome 12 open reading frame 42

chr18_+_69966725 0.402 NM_014177
C18orf55
chromosome 18 open reading frame 55
chr7_+_128290162 0.395 ATP6V1F
ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F
chr5_-_16561936 0.392 NM_019000
FAM134B
family with sequence similarity 134, member B
chr1_+_153374967 0.392 SLC50A1
solute carrier family 50 (sugar transporter), member 1
chr3_-_115258053 0.391 NM_020817
KIAA1407
KIAA1407
chr6_+_84626083 0.389 NM_016230
CYB5R4
cytochrome b5 reductase 4
chr19_-_49644470 0.388 NM_014518
ZNF229
zinc finger protein 229
chr19_-_41672176 0.387 NM_032838
NM_001145343
NM_001145344
NM_001145345
ZNF566



zinc finger protein 566



chr5_+_85949518 0.384 NM_001867
COX7C
cytochrome c oxidase subunit VIIc
chr19_+_40900965 0.380 MLL4
myeloid/lymphoid or mixed-lineage leukemia 4
chr17_+_30938433 0.380 AP2B1
adaptor-related protein complex 2, beta 1 subunit
chr17_-_18526296 0.374 NM_001145045
ZNF286B
zinc finger protein 286B
chr4_+_109763119 0.369 RPL34
ribosomal protein L34
chr12_+_119224506 0.368 NM_012240
SIRT4
sirtuin 4
chr22_+_37407925 0.361 TOMM22
translocase of outer mitochondrial membrane 22 homolog (yeast)
chr19_+_61344501 0.352 ZNF444
zinc finger protein 444
chr6_+_84626113 0.350 CYB5R4
cytochrome b5 reductase 4
chr5_+_85949511 0.346 COX7C
cytochrome c oxidase subunit VIIc
chr1_-_145608965 0.340 NM_016361
ACP6
acid phosphatase 6, lysophosphatidic
chr1_+_93418866 0.338 CCDC18
coiled-coil domain containing 18
chr19_+_40900757 0.337 NM_014727
MLL4
myeloid/lymphoid or mixed-lineage leukemia 4
chr19_+_62554445 0.334 NM_020657
ZNF304
zinc finger protein 304
chr12_+_54611212 0.327 NM_001345
DGKA
diacylglycerol kinase, alpha 80kDa
chr1_-_153379344 0.327 NM_018973
NM_153741
DPM3

dolichyl-phosphate mannosyltransferase polypeptide 3

chr15_-_27901628 0.322 TJP1
tight junction protein 1 (zona occludens 1)
chr1_+_32979930 0.319 NM_020888
KIAA1522
KIAA1522

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.96 4.44e-05 GO:0006355 regulation of transcription, DNA-dependent
1.87 9.72e-05 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.89 1.89e-04 GO:0051252 regulation of RNA metabolic process
1.82 1.90e-04 GO:0010468 regulation of gene expression
1.79 2.32e-04 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.83 2.72e-04 GO:0010556 regulation of macromolecule biosynthetic process
1.67 3.10e-04 GO:0060255 regulation of macromolecule metabolic process
1.76 3.67e-04 GO:0051171 regulation of nitrogen compound metabolic process
1.64 3.96e-04 GO:0031323 regulation of cellular metabolic process
1.64 4.17e-04 GO:0080090 regulation of primary metabolic process
1.74 1.01e-03 GO:0031326 regulation of cellular biosynthetic process
1.57 1.33e-03 GO:0019222 regulation of metabolic process
1.73 1.54e-03 GO:0009889 regulation of biosynthetic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.42 7.80e-14 GO:0043229 intracellular organelle
1.42 1.01e-13 GO:0043226 organelle
1.45 4.03e-12 GO:0043231 intracellular membrane-bounded organelle
1.45 4.63e-12 GO:0043227 membrane-bounded organelle
1.28 3.27e-09 GO:0044424 intracellular part
1.60 5.26e-09 GO:0005634 nucleus
1.26 2.26e-08 GO:0005622 intracellular
1.39 2.81e-03 GO:0044446 intracellular organelle part
1.38 3.51e-03 GO:0044422 organelle part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.97 9.31e-07 GO:0003677 DNA binding
2.00 4.34e-06 GO:0008270 zinc ion binding
1.89 1.21e-05 GO:0046914 transition metal ion binding
1.66 6.40e-05 GO:0003676 nucleic acid binding
1.45 1.36e-02 GO:0046872 metal ion binding
1.44 2.08e-02 GO:0043169 cation binding
1.43 2.29e-02 GO:0043167 ion binding